CARE is Committed to High-Quality, Scientific Research

The CARE Consortium serves as the scientific and operational framework for the Concussion Research Initiative of the Grand Alliance.  CARE is committed to conducting research with the utmost rigor and with strong attention to and adherence with regulatory and ethical obligations.

To learn more about the Aims of the CARE Consortium, click on each link below:

AIM 1: Create a national multi-site consortium as a sustainable framework to achieve the clinical and scientific, priorities of the Concussion Research Initiative of the Grand Alliance.

ADMINISTRATIVE AND OPERATIONS CORE (AOC): The AOC will serve as the centralized coordination center for the Longitudinal Clinical Study and Advanced Research Cores (CSC and ARC – see below), and Consortium members. Led by Thomas W. McAllister, M.D., chair of the IU School of Medicine, Department of Psychiatry, the AOC will provide fiduciary oversight for the CARE Coordinating Centers and provide Data and Analysis management, Bioinformatics, Biospecimen, and Clinical Trial Support (IRB/Regulatory coordination) resources.

AIM 2: To conduct a prospective, longitudinal, multi-center, multi-sport investigation that delineates the natural history of concussion in both men and women by incorporating a multi-dimensional assessment of standardized clinical measures of post-concussive symptomatology, performance-based testing (cognitive function, postural stability), and psychological health.

LONGITUDINAL CLINICAL STUDY CORE (CSC): The CSC will expand upon the existing NCAA National Sport Concussion Outcomes Study, a multi-site, longitudinal investigation of concussive and repetitive head impacts in NCAA student-athletes. The CSC will develop and implement a multi-year, multi-institution prospective, clinical longitudinal phase-in research protocol whose aim will be to study the natural history of concussion. The CSC will serve as the foundation upon which additional advanced research projects will be built

The University of Michigan will lead the Longitudinal Clinical Study Core, a prospective, multi-institution clinical research protocol whose aim will be to study the natural history of concussion among NCAA student-athletes and be the largest ever of its type. Steven Broglio, Ph.D., ATC, associate professor in the School of Kinesiology and director of the NeuroSport Research Laboratory, will lead the effort.

AIM 3: Utilize the framework of Aim 2 to conduct advanced scientific studies which integrate biomechanical, clinical, neuroimaging, neurobiological and genetic markers of injury to advance our understanding of neurophysiological effects and recovery after SRC in college athletes.

ADVANCED RESEARCH CORE (ARC): The ARC will leverage existing collaborative research networks (e.g., NIH TRACK-TBI, DoD Project Head to Head, NFL-GE Head Health Challenge) to conduct advanced research projects that include, but are not limited to, impact sensor technologies, advanced neuroimaging, biological markers and comprehensive clinical studies to inform the neurobiopsychosocial understanding of SRC.  Led by Dr. Michael McCrea, Professor of Neurosurgery and Director of Brain Injury Research at MCW, the ARC builds upon the CSC, thereby allowing for advanced research projects with the same foundational baseline and post-concussive clinical data.  Ultimately, the work is designed to more fully inform a comprehensive understanding of sport-related concussion and traumatic brain injury.



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NCAA • DOD Grand Alliance

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